Wednesday, December 29, 2021

A Day Like Today

 Remember Bryan Adams?

Today has been a day like the one in his song where I never want to see the sun go down.

An altogether perfect day- did some writing for the Rural Primary Care group, had some intense discussions on the same, did my taxes (at last!), took a nap, and after I woke up, I found the syllabus for a virology course that my buddy Dr.Chitra asked me to teach.

And this discovery is what has thrilled me to bits- the virology course is exciting! I'm reading Pranay Lal's book "The Invisible Empire" and all sorts of ideas are rattling around inside.  

Have decided that I will read 10 pages of the book every day and blog about the same. This way, the book will serve as my primary source material for the course and I'll become more familiar with my own field. This also means that I should be done with the first reading of the book in about a month, give or take a few days. 

RK and I usually take stock of our year and make plans for the next one around this time every year.  I usually categorise my plans into smaller bundles like "travel" or "scholarship" or "grant-related" or "how to make more money in a happy way". Last year, I realised that my scholarship output  for 2020 had been rather dismal and so this year, I really worked hard, got a publication out, got one more submitted, got my team to submit 5 abstracts at conferences (of which 4 have been accepted for oral presentations! And the 5th could win the video presentation category, with God's grace!) and gave multiple presentations at local, national and international forums. So I feel like having that discussion last year and making that plan for this year was really helpful in pushing me to achieve things. 

So for the next year, my scholarship plans will include my teaching this course, blogging about the learning I've gleaned from this book and others that I study for the course, getting my team to write two papers (with them taking the initiative, and me as the mentor), and me taking the initiative on two papers myself. Plus, I know that our larger group itself has a couple of papers planned so I'll get to be on those as well. 

So really, this course is something that is new and I'm looking forward to it. Maybe next year, I'll pick another course to teach so I constantly keep learning things that are useful to me. 


Tuesday, December 28, 2021

A message from the universe?

 Just finished an application for the Goldman Sach's 10000 Women Program at NSRCEL, IIMB.

Then got an email from Niti Aayog saying that there is a Women Transforming India award under the Women Entrepreneurship Program and that the last date is day after tomorrow. So checked that out and decided to apply.

Then got a call from my friend Dr. Prasoon reminding me that I had agreed to speak at NIT Rourkela and that he specifically wanted me to speak about being a woman entrepreneur.

Talk about coincidences... 

I think what the universe may be trying to tell me is that it's time I put my mind to actualizing a plan for what I say I intend to do: transform primary care and public health diagnostics. With each of these applications or events being more detailed than the previous, I will need to think hard about how I intend this to happen more than just mention that I will do it.

So...  I will choose to see this as yet another way by which my faith in the universe makes what I want happen. 

Wednesday, December 22, 2021

Bolero and the Brain

 Whenever there are discussions on babies and their development (With the various lockdowns that we have had, is it any surprise that so many people around us are now having babies? 4 couples currently that I know of had babies within weeks of each other), the question of music and babies invariably pops up. 

Unfortunately, there is not a lot of published scientific work on the long term effects of classical Indian (or really, any non-Western classical) music on brain development, even though there are plenty of anecdotal reports of how listening to Hindustani or Carnatic instrumental or vocal music influence enhances overall brain development, builds nascent musical talent etc. Recently, there was an entire issue devoted to "Music in the Lives of Young Children" in the journal Early Child Development and Care. One of the articles in this issue was on the effect of Carnatic music on the mathematical abilities of young children aged 5 and 8 (listening to Carnatic music significantly improved mathematical ability).

We all read about how listening to Mozart is supposed to make babies brainier and programs like Little Einstein try to introduce short fragments of Western classical music to toddlers. When I was pregnant with Ani, Lori, my labmate in the Pittsburgh Retrovirology Lab, at Pitt, had shared a CD (those days, we still had CDs!) that was a compilation of well known symphonies. It had the usual suspects- Eine Kleine Nachtmusik, Beethoven's 5th and 9th symphonies, The Blue Danube etc. Then, right at the end, as though giving a small nod to a more modern time, the CD included Ravel's Bolero. Have you heard this? Depending on your mood, it could either be haunting or utterly annoying. That tune, once you have heard it, never gets out of your head.

Any time the CD reached Bolero, I would lunge towards the player and stop the track and breathe a sigh of relief if I managed it before the first strains of that tune started. However, many times, regardless of whether or not I managed to either shut down the system or skip the track, the tune would have already started inside my head, relentlessly marching forth in that unmistakable whiny tone set to the backdrop of that military beat.

Today, after nearly a decade of Bolero-freedom, I sought it willingly because I had forgotten how infuriating it is. And I also learned a little more about Marcel Ravel. 

Ravel apparently started un-Raveling (haha!) right about the time that he wrote Bolero. This near constant obsession with the same tune came around the same time that he started showing early signs of a mental disorder called that progressively affected his language and motor ability. People think now that he suffered from a condition called PPA and CBD. In this paper from last year, a group of scientists described  the obsession of another artist with Bolero. This artist (and former scientist), Anne Adams, painted the elements of Bolero with great attention to detail. Coincidentally, this phase corresponded to an early phase of subclinical PPA in her as well.  As her dementia and aphasia progressed, her paintings became increasingly photographic representations of what she saw around her. 

Below are the paintings and information about them as well as her clinical status as per the paper “Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex” in the journal Brain in 2020.

 Painting done by Anne Adams in 1991, 9 years before clinical symptoms of PPA 

Unraveling Bolero; done in 1994, 6 years before PPA symptoms 
Representation of pi, 1998, 2 years before her clinical symptoms

ABC Book of Invertebrates, done in 2000, the year her symptoms were apparent and she was diagnosed with PPA



Arbutus Leaves, painted 2 years after diagnosis in 2002






Amsterdam, painted in 2004, 4 years after diagnosis. By this time, she was unable to communicate through spoken language. 











Here is a CT scan of her brain against the phases after diagnosis


Finally, the authors say 
 , "AA was enchanted by Ravel's ‘Boléro’, composed by a man with the same syndrome, PPA, and possibly the same underlying histopathology, CBD (Baeck, 1996; Amaducci et al., 2002). AA's interest in ‘Boléro’ arose before she developed overt PPA symptoms or learned of Ravel's illness. Furthermore, AA painted ‘Unravelling Bolero’ at nearly the same age and disease stage that characterized Ravel when he wrote ‘Bolero’, suggesting that some patients with early PPA may be drawn to themes of repetition, texture and symmetry, perhaps because their thriving posterior cortices are increasingly tuned to these stimulus qualities. Whatever its basis, the relationship between AA and Ravel sheds new light on how neural systems interact to enhance the creative process"



So while Bolero might still make me lunge to turn it off and yet stay in my head forever, now I will have this additional amazing story to think about. Repetitions, symmetry etc are attractive to people with certain neural traits. While the link between art and mental disease is well known (you can see this by Googling schizophrenia and art), to me, these case studies and research work also highlight the importance of art in people with mental disorders: that such amazing works of art were made by Anne Adams even as her disease progressed to me indicates that perhaps creativity and art might even slow down mental disorders... I suppose that is a separate story altogether.











Sunday, December 12, 2021

Ongoing Lessons in Faith

 Working on it...getting better.... reading books that help me with it, like those by Napoleon Hill and Wayne Dyer. 

There are still occasions of fear but for the most part, been replaced by steely resolution that I WILL NOT fail and I WILL ask for help and have faith that the HELP WILL COME.

And in addition to all this, have decided that the best way to embrace faith is to see everyone in my journey as an ally... not in a naive, rose tinted glasses kind of way, but in an open, honest way that accepts and acknowledges conflicts of interest, conflicting or opposing priorities and yes, competition too.